Volume 14, no. 4
Pages 54-58

The objective of our research was to determine correlation between the level of corticosterone, behavioral activity and the initial resistance to hypoxia. The study was performed on 46 white rats. Animals initially exposed to hyperbaric hypoxia. According to the results of testing the animals were divided into highly resistant (HR) and low resistant (LR), and intermediately resistant animals (IR). In the blood plasma corticosterone content was determined. In the liver we estimated activity of succinate dehydrogenase (SDH) and monoamine oxidase (MAO-B) Behavioral activity was evaluated in the open field test. IR animals had initially higher corticosterone levels than in intact animals and HR animals as well as LR animals. IR animals were characterized by greater endurance while swimming at low temperature. IR animals surpass other animals in adaptive capabilities.

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Sources:

1. Balashov Yu.G. [Fluorometric Micromethod of Determination of Corticosteroids. A Comparison with Other Methods]. Fiziologicheskiy zhurnal SSSR [Physiological Journal SSSR], 1998, no. 12, pp. 280–283. (in Russ.)
2. Volchegorskiy I.A., Dolgushin I.I., Kolesnikov O.L., Tseylikman V.E. Eksperimental'noe modelirovanie i laboratornaya otsenka adaptatsionnykh reaktsiy organizma [Experimental Modeling and Laboratory Evaluation of Adaptive Reactions]. Chelyabinsk, Chelyabinsk State Pedagogical University Publ., 2000. 167 p.
3. Zhukov D.A. Biologiya povedeniya: gumoral'nye mekhanizmy: Biologiya povedeniya. Gumoral'nye mekhanizmy [Biology Behavior Humoral Mechanisms. Biology Behavior Humoral Mechanisms]. St. Peterburg, Speech Publ., 2007. 443 p.
4. Pertsov S.S., Koplik E.V., Kalinichenko L.S. [The Intensity of the Oxidant and Antioxidant Processes in the Brain of Rats with Different Parameters of Behavior in Acute Stressor Load]. Byulleten' eksperimental'noy biologii i meditsiny [Bulletin of Experimental Biology and Medicine], 2011, vol. 152, no. 7, pp. 4–8. (in Russ.)
5. Armario A. The Hypothalamic-Pituitary-Adrenal Axis: What Can it Tell Us About Stressors? CNS & Neurological Disorders-Drug Targets (Formerly Current Drug Targets-CNS & Neurological Disorders), 2006, vol. 5, no. 5, pp. 485–501.
6. Dallman M.F. Modulation of Stress Responses: How we Cope With Excess Glucocorticoids. Experimental Neurology, 2007, vol. 206, no. 2, pp. 179.
7. De Kloet E.R. Hormones and the Stressed Brain. Ann. N.Y. Acad. Sci., 2004, pp. 1–15.
8. Gold P.W., Chrousos G.P. Melancholic and Atypical Subtypes of Depression Represent Distinct Pathophysiological Entities: CRH, Neural Circuits, and the Diathesis for Anxiety and Depression. Mol Psychiatry, 2013, vol. 18 (6), pp. 632–634.