Volume 14, no. 4
Pages 14-19

We analyzed open regulation system of blood acid-base balance and its correlation with system of acid equivalent generation in muscles at intensive physical exertion. This analysis allowed us of making a hypothesis that human body has reserve of unused activity of mitochondrial energy supply, and the problem of physical working capacity increase at metabolic acidosis may be solved by supporting energy balance of mitochondria with provided substrate that is able to oxidize and provide aerobic ATP re-synthesis in conditions of working hypoxia.

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Sources:

1. Mohazzab-H K.M., Kaminski P.M., Wolin M.S. Lactate and PO2 Modulate Superoxide Anion Production in Bovine Cardiac Myocytes: Potential Role of NADH Oxidase. Circulation, 1997, vol. 15, no. 96(2), pp. 614–620.
2. Becker L.B., Vanden Hoek T.L., Shao Z.H., Li C.Q., Schumacker P.T. Generation of Superoxide in Cardiomyocytes During Ischemia before Reperfusion. Am J Physiol, 1999, vol. 277, pp. 2240–2246.
3. Halestrap A.P., Doran E., Gillespie J.P., O’Toole A. Mitochondria and Cell Death. Biochemical Society Transactions, 2000, vol. 28, no. 2, pp. 170–177.
4. Skulachev V.P. Mitochondria in the Programmed Death Phenomena; a Principle of Biology: “It Is Better to Die than to be Wrong”. IUBMB Life, 2000, vol. 49, no. 5, pp. 365–373.
5. Yakovlev N.N. [Biochemical Mechanisms of Skeletal Muscle Adaptation to Increased Activity]. Ukrainskiy biokhimicheskiy zhurnal [Ukrainian Biochemical Journal], 1976, vol. 48, no. 3, pp. 38–39.
6. Hendrikx M., Mubagwa K., Verdonck F. New Na(+)–H+ Exchange Inhibitor HOE 694 Improves Postischemic Function and High-Energy Phosphate Resynthesis and Reduces. Ca2+ Overload in Isolated Perfused Rabbit Heart. Circulation, 1994, vol. 89 (6), pp. 2787–2798.
7. Kondrashova M.N., Maevskiy E.I., Babayan G.V. [Adaptation to Hypoxia by Switching Metabolism on the Conversion of Succinic Acid]. Mitokhondrii. Biokhimiya i ul'trastruktura [In the Collection. Mitochondria. Biochemistry and Ultrastructure], 1973, pp. 112–129. (in Russ.)
8. Sel’kov E.E., Biochem J. Stabilization of Energy Charge Oscillations and Multiplicity of Stationary States in Energy Metabolism as a Result of Purely Stoichiometric. Regulation. J. Biochem., 1975, vol. 59, pp. 151–160.