Volume 14, no. 1
Pages 88-95

   Objective: to study the hemostasis system indices and systemic inflammatory response in pregnant women with moderate and severe preeclampsia. In the study “case-control” there were 14 women without preeclampsia (control group), 16 women with moderate preeclampsia and 14 – with severe one. We have studied hemostasis indices (D-dimer, prothrombin index, antithrombin III, activated partial thromboplastin time, fibrinogen, XIIa-dependent and euglobulin fibrinolysis, soluble fibrin-monomeric complex, thrombocyte aggregation with ADP, adrenalin, collagen) and systemic inflammation (hsCRP, endotoxin). In moderate preeclampsia we registered decrease in thrombocyte count (180.00 ± 5.15×109/l) and increase in their induced aggregation (with ADP – 5 73.52 ± 1.35 %, АDP – 0.5 4.47 ± 0.11 %, adrenalin – 70.89 ± 1.10 %, collagen – 82.73 ± 1.71 %), we also revealed the hemostasis activation markers (D-dimer increasing – 1971.88 ± 391.99 ng/ml, fibrinogen increasing – 6.68 ± 0.26 g/l, antithrombin III activity decreasing – 97.96 ± 4.00 %) and the markers of systemic inflammation (rising of hsCRP – 6.42 ± 0.85 mg/l, endotoxin – 8.46 ± 0.67 EU/ml). Compared with moderate preeclampsia the severe one is characterized by more expressed thrombocyte count (155.57 ± 6.45×109/l) with thrombocyte disaggregation predisposition (increasing of aggregation with adrenalin – 73.95 ± 2.92 %, decreasing – with ADP 0.5 – 2.52 ± 0.16 %), significant hypercoagulation shifts (increase of D-dimer – 1653.71 ± 234.52 ng/ml, soluble fibrin-monomeric complex – 

15.39 ± 1.10 mg%, fibrinogen – 6.57 ± 0.15 g/l, decreasing of antithrombin III activity – 91.74 ± 4.29 %, retardation of euglobulin and XIIа-dependent fibrinolysis 298.36 ± 12.17 min and 18.19 ± 1.77 min accordingly) and rising of inflammatory response markers (hsCRP 8.02 ± 1.02 mg/l, endotoxin 9.52 ± 0.81 EU/ml). We found out positive correlation relationships of hsCRP-level and endotoxin with coagulation hemostasis indices (D-dimer, soluble fibrin-monomeric complex, fibrinogen), vascular-thrombocytic hemostasis (thrombocyte count, thrombocyte aggregation with ADP), anticoagulative system (XIIa-dependent fibrinolysis) and negative correlation relationships with antithrombin III activity. Systemic inflammation markers (hsCRP, endotoxin) and hemostasis system indices (D-dimer, soluble fibrin-monomeric complex, fibrinogen, thrombocyte count, thrombocyte aggregation with ADP, XIIa-dependent fibrinolysis, antithrombin III) may be used as the criteria of preeclampsia severity. Keywords: preeclampsia, systemic inflammation indices, hemostasis system. 

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